mmm I didn't really like it
Yes, I am bit biased when it comes tom anime-ish stuff on newgrounds, It's not a style I really appreciate, but I can respect it at times. I'm not saying I don't respect yours, It's obvious you put effort into it and just because of that it deserves some respect, BUT: I didn't feel the characters or story were very original (although obviously more original then mario or sonic or most sprites... can't believe how much of that there is), but their whole outfit and ears and tails and hair and... well, all in general, it seems just like a mix and match of all anime work out there on newgrounds. The story as well -a weird quirky relationship where one is all stuck up and serious, while the other is all jumpy and cutesy- see what I mean, its quite cliche'd. Sometimes a cliche can be executed so awesomely that it works, but I don't think this is the case, and I don't think it should be what you're aiming for.
Anyways, it seems like you enjoy this sort of thing and are willing to get better everytime, so I hope to see more from you in the future. And if you consider what I mentioned before, try to dig a bit deeper, maybe put a bit more of you in it or think of a more unique perspective or experience. Of course I'm no expert on the subject, (I haven't been frontpaged like you haha), but I hope my advice helps.
Good luck